Factor XIIa

Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.

Also Known As:

Coagulation Factor XIIa; Activated Factor XII; Blood Coagulation Factor XII, Activated; Factor 12A; Factor Twelve A; Hageman-Factor Fragments; Prekallikrein Activator; Activator, Prekallikrein; Factor XIIa, Coagulation; Fragments, Hageman-Factor; Hageman Factor Fragments; Factor XII, Activated

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Serine Proteases: 3726
        Serine Endopeptidases: 11
        Factor XIIa: 108
      - Endopeptidases: 633
        Serine Endopeptidases: 11
        Factor XIIa: 108
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Blood Coagulation Factors: 5376
      - Factor XII: 692
        Factor XIIa: 108
Biological Factors: 2472
- Blood Coagulation Factors: 5376
  - Factor XII: 692
    - Factor XIIa: 108

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Disease

Drug/Important Bio-Agent (IBA)